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Effects of methyl-beta-cyclodextrin on blood-brain barrier permeability in angiotensin II-induced hypertensive rats

Müge Atış,Uğur Akcan,Canan Uğur Yılmaz,Nurcan Orhan, Poyraz Düzgün, Umut Deniz Ceylan,Nadir Arıcan,Serçin Karahüseyinoğlu,Gizem Nur Şahin,Bülent Ahıshalı,Mehmet Kaya

Brain Research（2019）

Cited 11|Views23
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Abstract
•Acute hypertension increases BBB permeability via caveolae-mediated endocytosis.•MBCD does not have an impact on the disruption of BBB during acute hypertension.•MBCD causes BBB disruption and increases BBB permeability in normotensive rats.
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Key words
Acute hypertension,Methyl-β-cyclodextrin,Blood-brain barrier,Claudin-5,Caveolin-1,Horseradish peroxidase
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