Retrospective Analysis of the Efficacy of Dapagliflozin in Patients with Type 2 Diabetes in a Primary Clinic in Korea.

Background: We aimed to retrospectively analyze the efficacy of 10 mg dapagliflozin (DAPA), which is a sodium-glucose cotransporter-2 inhibitor, in Korean patients with type 2 diabetes who visited a primary diabetes clinic. Methods: In total, 83 patients with type 2 diabetes, who received treatment with DAPA for the first time in a primary diabetes clinic between January 2015 and October 2015, were included in the study. The effect of DAPA in lowering glycosylated hemoglobin (HbA1c) levels was evaluated via chart review at 6 months follow-up. The patients were categorized into five groups according to add-on to or switched from other glucose-lowering agents: add-on to metformin (MET, n=10), add-on to MET+dipeptidyl peptidase 4 inhibitor (DPP4i, n=12), switched from sulfonylurea (SU, n=13), switched from DPP4i (n=11), and switched from thiazolidinedione (TZD, n=37). All the participants had already used MET for their regimen. Results: Treatment with DAPA reduced HbA1c level by 1.2%+/- 0.8%. Moreover, a significant decrease was observed in all subgroups: add-on to MET, -1.2%+/- 0.7%; add-on to MET+ DPP4i, -1.4%+/- 0.8%; switched from SU, -1.4%+/- 0.7%; switched from DPP4i, -0.5%+/- 0.7%; and switched from TZD, -1.2%+/- 0.9% (P< 0.01). A significant decrease in body weight (-3.1 +/- 2.6 kg, P< 0.001) was observed after DAPA administration. Estimated glomerular filtration rate and urine microalbumin were significantly decreased after 6 months of treatment with DAPA (-4.0 +/- 13.5 mL/min/1.73 m(2), P=0.03; -23.6 +/- 45.9 mg/L, P< 0.001). Conclusion: Treatment with DAPA, whether added to or switched from other glucose-lowering agents, significantly decreased HbA1c levels in Korean patients with type 2 diabetes who visited a single primary diabetes clinic. DAPA can be considered as an optimal second-line treatment for patients with type 2 diabetes, as supported by real-world evidence studies.