The efficacy and safety of multiple doses of oral tranexamic acid on blood loss, inflammatory and fibrinolysis response following total knee arthroplasty: a randomized controlled trial.

•Multiple boluses of oral TXA could reduce blood loss, Hb and Hct drop in primary TKA.•There was no evidence for an increase in the risk of complications with the application of multiple boluses of oral TXA in primary TKA.•Multiple boluses of oral TXA could further restrain postoperative inflammatory and fibrinolytic response in primary TKA.