Cannabidiol attenuates mechanical allodynia in streptozotocin-induced diabetic rats via serotonergic system activation through 5-HT1A receptors.
Brain Research(2019)
Abstract
•Cannabidiol exerts significant anti-allodynic effect in diabetic neuropathic pain.•Cannabidiol does not alter locomotor activity in diabetic animals.•5-HT1A receptors mediate the effect of cannabidiol in diabetic neuropathic pain.•Cannabidiol may induce an increase of spinal cord levels of serotonin in diabetic rats.
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Key words
Diabetes,Neuropathic pain,Cannabinoids,Cannabinoid receptors,Serotonin
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