Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease.

Adam R Smith,Rebecca G Smith,Ehsan Pishva,Eilis Hannon,Janou A Y Roubroeks,Joe Burrage,Claire Troakes,Safa Al-Sarraj,Carolyn Sloan,Jonathan Mill,Daniel L van den Hove,Katie Lunnon

Clinical epigenetics（2019）

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摘要

Our study represents the first epigenome-wide association study of both DNA methylation and hydroxymethylation in Alzheimer's disease entorhinal cortex. We demonstrate that previous estimates of DNA hypermethylation in ANK1 in Alzheimer's disease were underestimates as it is confounded by hypohydroxymethylation.

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关键词

Alzheimer’s disease (AD),Ankyrin 1 (ANK1),Brain,DNA hydroxymethylation (5hmC),DNA methylation (5mC),Entorhinal cortex (EC),Epigenetics,Epigenome-wide association study (EWAS),Illumina Infinium Human Methylation 450K microarray (450K array)

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