Diallyl Trisulfide can induce fibroblast-like synovial apoptosis and has a therapeutic effect on collagen-induced arthritis in mice via blocking NF-κB and Wnt pathways

•DATS decreases proliferation and induces apoptosis in RA-FLS.•DATS attenuates inflammatory reactions both in vitro and vivo.•These effects of DATS might be ascribed to its inhibitory effect on the NF-κB and Wnt signaling pathways.•DATS may also exert a therapeutic effect by regulating the balance of IL17/Treg.•DATS might be a potential candidate for RA treatment.