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Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672.

Michael G. Yang,Zili Xiao,Robert J. Cherney,Andrew J. Tebben,Douglas G. Batt,Gregory D. Brown,Jing Chen,Mary Ellen Cvijic,Marta Dabros,John V. Duncia, Michael Galena,Daniel S. Gardner,Purnima Khandelwal,Soo S. Ko,Mary F. Malley,Ruowei Mo,Jian Pang,Anne V. Rose,Joseph B. Santella,Hong Shi,Anurag Srivastava,Sarah C. Traeger,Bei Wang,Songmei Xu,Rulin Zhao,Joel C. Barrish,Sandhya Mandlekar,Qihong Zhao,Percy H. Carter

ACS Medicinal Chemistry Letters（2019）

Cited 14|Views2
Key words
Chemokine,G protein-coupled receptor,conformational analysis,hydrogen bonding,oral bioavailability,ion channels
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