Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated Ir III Complex Conjugated to a Far-Red Emitting Coumarin.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(2019)
Abstract
Although cyclometalated Ir-III complexes have emerged as promising photosensitizers for photodynamic therapy, some key drawbacks still hamper clinical translation, such as operability in the phototherapeutic window and reactive oxygen species (ROS) production efficiency and selectivity. In this work, a cyclometalated Ir-III complex conjugated to a far-red-emitting coumarin, Ir-III-COUPY, is reported with highly favourable properties for cancer phototherapy. Ir-III-COUPY was efficiently taken up by HeLa cells and showed no dark cytotoxicity and impressive photocytotoxicity indexes after irradiation with green and blue light, even under hypoxia. Importantly, a clear correlation between cell death and intracellular generation of superoxide anion radicals after visible light irradiation was demonstrated. This strategy opens the door to novel fluorescent photodynamic therapy agents with promising applications in theragnosis.
MoreTranslated text
Key words
conjugation,coumarin,cyclometalated iridium(III) complexes,photodynamic therapy,photosensitizer
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined