Efficacy of novel recombinant fowlpox vaccine against recent Mexican H7N3 highly pathogenic avian influenza virus.

Miria Ferreira Criado,Kateri Bertran,Dong-Hun Lee,Lindsay Killmaster,Christopher B Stephens,Erica Spackman,Mariana Sa E Silva,Emily Atkins,Teshome Mebatsion,Justin Widener,Nikki Pritchard,Hallie King,David E Swayne

Vaccine（2019）

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摘要

•rFPV-H7/3002 vaccine protected chickens against challenge Mexican 2015 H7N3 HPAIV.•rFPV-H7/2155 vaccine protects against the 2012 outbreak virus but not 2015 H7N3 HPAIV.•2015 Mexican H7N3 HPAIV have gained additional N-glycosylation sites on the HA.•The importance of updating vaccines for long-term effective control of H7 HPAIV.

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关键词

Chickens,High pathogenicity avian influenza,H7N3,Immunity,Recombinant fowlpox virus vaccine,Vaccine

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