Docosahexaenoic acid and TUG-891 activate free fatty acid-4 receptor in bovine neutrophils.

Ivan Olmo,Stefanie Teuber,Camilo Larrazabal,Pablo Alarcon, Fernanda Raipane,Rafael A Burgos,Maria A Hidalgo

Veterinary Immunology and Immunopathology（2019）

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摘要

•Neutrophils express the free fatty acids (FFA) 4 receptor, which is activated by docosahexaenoic acid (DHA) and TUG-891.•DHA and TUG-891 increased matrix metalloproteinase (MMP)-9 granules release and superoxide production.•Intracellular calcium is key in FFA4 agonists-induced superoxide production.

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关键词

FFA4,DHA,MMP-9,ROS,LCFAs,COX-2,FFA,GPCR,NETs

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