Continuous Versus Interrupted Use Of Vaginal Probiotics Plus Vaginal Clindamycin Cream For Bacterial Vaginosis: A Randomized Controlled Study

Purpose: To compare between continuous and interrupted use of vaginal probiotic after vaginal clindamycin cream for treatment and prevention of recurrence of bacterial vaginosis.Methods: A double-blinded randomized controlled clinical trial, 273 women were randomly allocated to use clindamycin 2% vaginal cream 5g at bedtime for 7days followed after 1week by continuous probiotics vaginal capsule once daily for 6weeks (n=129) or clindamycin 2% vaginal cream 5g at bedtime for 7days followed by one probiotic vaginal capsule twice a week for 6weeks (n=144). The initial evaluation was at 1week after cessation of probiotics treatment to estimate the cure rates, the follow-up visits were at 1, 3, 6, and 9months from the initial visit. The primary outcome of this study was cure rate; the secondary outcomes were the frequency of recurrence, the presence of vaginal discharge, pH > 4.5, positive whiff test and detection of clue cells.Results: At the initial visit there was no significant difference in cure rate between continuous probiotics group and interrupted probiotics group (87.4 versus 82.5%; p=.81). There was no significant difference between the two groups in the recurrence rate at one, three, six and 9months follow up visits (p=.16, p=.42, p=.59, p=.66). There was no significant difference between both groups regarding vaginal discharge reduction, pH dropping, the presence of positive whiff test and detection of clue cells at one, three, six and 9months follow up visits. Except at 9-month visits, the differences in vaginal discharge reduction and positive whiff test were statically significant.Conclusions: After initial treatment of bacterial vaginosis with vaginal clindamycin cream, the continuous use of vaginal probiotics is equally effective to short repetitive courses in terms of cure rates and prevention of relapse.