Sex differences in subacute manganese intoxication: Oxidative parameters and metal deposition in peripheral organs of adult Wistar rats

Carine Raquel Richter Schmitz,Tuany Eichwald,Maria Victória Branco Flores,Karina Giacomini Varela,Analu Mantovani,Jovani Antônio Steffani,Viviane Glaser,Diego de Carvalho,Aline Pertile Remor

Regulatory Toxicology and Pharmacology（2019）

Cited 9|Views7

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Abstract

•Subacute Mn contributes to oxidative/metabolic impairment, metal deposition and morphological lesion in peripheral organs.•Mainly impairment was observed in kidney and liver after subacute Mn intoxication.•Oxidative and metabolic impairment affects both male and female adult Wistar rats, although in the different manner.•Overall male rats showed more intense deleterious effect in peripheral organs.

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Key words

Manganese deposition,Subacute intoxication,Peripheral oxidative stress,Sex difference

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