NK-cell responses are biased towards CD16-mediated effector functions in chronic Hepatitis B virus infection.

Anita Schuch, Britta Franziska Zecher,Philipp Andreas Müller,Margareta P Correia,Franziska Daul,Charlotte Rennert,Catrin Tauber, Karolin Schlitt,Tobias Boettler,Christoph Neumann-Haefelin,Hartmut Hengel,Hanspeter Pircher,Adelheid Cerwenka,Robert Thimme,Maike Hofmann

Journal of Hepatology（2019）

引用 26|浏览51

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摘要

•Frequent HBV/HCMV co-infection is associated with the expansion of memory-like NK cells.•Memory-like NK cells are largely conserved in chronic hepatitis B virus infection.•Memory-like NK cells determine the NK-cell response in chronically hepatitis B virus-infected patients.•Adaptive antibody-dependent NK-cell response is increased in chronic hepatitis B virus infection.

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关键词

NK cells,Chronic hepatitis B virus infection,Human cytomegalovirus,CD16,Memory-like,Adaptive

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