Fluid-structure interaction in intracranial vessel walls: The role of patient-specific wall thickness
Current Directions in Biomedical Engineering(2018)
摘要
AbstractComputational Fluid Dynamics studies try to support physicians during therapy planning of intracranial aneurysms. However, multiple assumptions (e.g. rigid vessel walls) are required leading to a sparse acceptance of numerical approaches within the medical community. This study incorporates multiple fluid-structural simulations for an intracranial basilar artery bifurcation. Based on a patient-specific dataset, which was acquired using optical coherence tomography, minimum, mean, maximum, and diameter-dependent thicknesses were generated and compared w.r.t. hemodynamic and wall stress parameters. The comparison of different wall thickness models revealed a strong variability among the analyzed parameters depending on the corresponding assumption. Using the patient-specific configuration as a reference, constant thicknesses lead to differences of up to 100 % in the mean wall stresses. Even the diameter-dependent thickness results in deviations of 32 %, demonstrating the wide variability of computational predictions due to inaccurate assumptions. The findings of this study highlight the importance of geometry reconstruction including accurate wall thickness reproduction for fluid-structure simulations. Patient-specific wall thickness seems to be out of alternatives regarding the realistic prediction of wall stress distributions.
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关键词
fluid-structure interaction,computational fluid dynamics,intracranial aneurysm,wall thickness
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