Clinico-Pathologic Features And Survival In Elderly Patients Vs. Older And Younger Adults With Glioblastoma Multiforme: An Exploratory Analysis Of A Series Of Consecutive Patients

e14071 Background: Clinicopathologic characteristics and outcomes between older and younger glioblastoma multiforme (GBM) patients may differ. Methods: With approval of IRB, we conducted retrospective analysis in 156 consecutive patients (n = 156) with GBM treated at our insitution in 2007-2017. 79 patients were seventy years of age or younger (≤70) and 79 were older than seventy ( > 70). Clinicopathologic features, therapy and survival were compared between two cohorts. Statistical analysis: Significance of associations was assessed via Fishers' exact test. Survival analysis was performed via Cox proportional model with censoring to calculate hazard ratios (HR). Results: Compared to patients ≤70, the patients > 70 were less likely to undergo surgery (34% vs 64%; p = 0.0003), be treated with adjuvant chemotherapy (37% vs 59%; p = 0.01) or radiation therapy (36% vs 56%; p = 0.03). Survival was worse in patients > 70 as opposed to patients ≤70 (average time to death 726 vs. 935 days; HR 0.53, p = 0.04). Patient gender, primary tumor size and use or radiation therapy did not correlate with survival. There was no significant difference in terms of primary brain tumor location between the two cohorts. Time to death correlated positively with surgical excision (1138 vs 733 days; HR 0.57, p = 0.004) and use of chemotherapy (935 vs 729 days; HR 0.59, p = 0.04). Conclusions: Older GBM patients displayed significantly shorter survival than their younger counterparts. They were less likely to receive surgery, adjuvant chemotherapy and/or radiation therapy. Our multivariate analysis suggests that both age groups derived benefit from surgical excision and chemotherapy. As our study is limited by sample size, larger studies are needed to confirm the significance of our findings.