Chia oil supplementation changes body composition and activates insulin signaling cascade in skeletal muscle tissue of obese animals.

•Chia oil supplementation increases insulin sensitivity in obese mice.•Chia oil supplementation promotes IRS-1, AKT, and GLUT4 activation in skeletal muscle tissue of obese mice.•Obese animals treated with chia oil exhibit a shift between fat and lean mass.•Chia oil supplementation minimizes the symptoms of the metabolic syndrome.