C677T and A1298C polymorphisms of Methylenetetrahydrofolate reductase (MTHFR) gene: Effect and risk to develop chronic myeloid leukemia: A study on Syrian patients

Methylenetetrahydrofolate reductase (MTHFR) gene is essential in folate metabolism. Genetic variations in this gene like 677 C>T and 1298 A>C affect its activity; the latter could act efficiently the DNA methylation and may give susceptibility to different malignancies. Not surprisingly, different studies have described a relationship between the presence of 677 C>T and 1298 A>C MTHFR polymorphisms and the leukemia risk development. However, only few studies have reported this issue in CML.