146 Effects of depression status on penile hemodynamics in men with erectile dysfunction

Depression is an important psychological factor that is associated with erectile dysfunction (ED). However, to date, few studies have been conducted on the organic pathologic changes caused by depression. This study aims to investigate the effects of depression on penile hemodynamics in Chinese men with ED. Male subjects aged 20-50 years with ED complaint were screened by a detailed questionnaire that allowed analyses of their sexual experience and history. Men with acute and/or chronic disease (including diagnosed hypertension and diabetes) and those receiving long-term pharmacotherapy were excluded. Evaluation of ED was conducted by the International Index of Erectile Function-5 (IIEF-5). Detection of penile hemodynamic was based on oral PDE-5 inhibitor usage combined with audiovisual sexual stimulation. A self-rating depression scale (SDS) was used to evaluate the depression status; and the depression score index (DSI) was calculated as total SDS scores divided by 80. Depression status and non-depression status were defined as DSI ≥0.5 and DSI <0.5, respectively. Biochemical indicators related to metabolism (including fasting blood glucose, insulin, cholesterol and triglyceride) and sex hormones were detected. Comparison analyses on the data between depression and non-depression groups were conducted.