Copper-catalysed cross-coupling of alkyl Grignard reagents and propargylic ammonium salts: stereospecific synthesis of allenes.
CHEMICAL COMMUNICATIONS(2018)
摘要
Herein we describe a robust and practical method to prepare enantiomerically enriched trisubstituted allenes using alkyl Grignard reagents and bench stable propargylic ammonium salts. Excellent yields as well as regio- and stereoselectivities are observed. Our conditions provide a solution to the allene racemization, which has been a long-standing problem when using Grignard reagents.
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关键词
alkyl grignard reagents,propargylic ammonium salts,stereospecific synthesis,copper-catalysed,cross-coupling
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