Supramolecular Threading of Peptide Hydrogel Fibrils
ACS Biomaterials Science & Engineering(2018)
Abstract
There is an increasing demand for biocompatible materials in biomedical applications. Herein, we report a modified α-helical decapeptide segment from the cardiac troponin C, which self-assembles into fibers with a secondary β-sheet structure. These fibers cross-link via a novel supramolecular threading mechanism which results in an atypical stiff hydrogel (G' ≈ 13 kPa). In this work, we provide a first insight into the understanding of such remarkable cross-linking mechanism, which will aid in the development of new biomaterials with unique properties.
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Key words
hydrogels,supramolecular,threading,biomaterials,fibrils,self-assembly
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