Methylation changes and aberrant expression of FGFR3 in Lewy body disease neurons.

Takeyuki Tsuchida,Tatsuo Mano,Kagari Koshi-Mano,Taro Bannai,Tomoyasu Matsubara,Satoshi Yamashita,Toshikazu Ushijima,Kenichi Nagata,Shigeo Murayama,Tatsushi Toda,Shoji Tsuji,Atsushi Iwata

Brain Research（2018）

引用 7|浏览17

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摘要

•Among the FGFR family, only neuronal expression of FGFR3 was increased in LBD brains.•Neuron specific methylation analysis revealed higher methylation level of FGFR3 gene body in LBD neurons.•Altered methylation status was associated with the severity of α-synuclein pathology.

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关键词

BDNF,DLB,DNA,EGFR,FGF,FGFR,LBD,MAPK,NC,PD,PDD,PCR,PDGFR,RNA

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