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Salvianolic acid B alleviate the osteoblast activity decreasing under simulated microgravity by Keap1/Nrf2/ARE signaling pathway

Rui Wang,Yan Diao, Wen Kuang,Qiao Li,Ye Tian, Jie Gao, Longfei Dai, Lulu Cao, Wenbo Wang,Lijun Wei

Journal of Functional Foods（2018）

Cited 6|Views23
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Abstract
•Salvianolic acid B was found to prevent bone loss in space.•The mechanism of bone loss in space may be though oxidative stress.•Salvianolic acid B can promote osteoblast proliferation and activity.•SaL B can increase the activity of antioxidant enzymes and the expression of bone formation genes.
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Key words
Salvianolic acid B,Osteoblast,Simulated microgravity,Antioxidant
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