A phase I, single-arm, open-label, dose escalation study of intraperitoneal cisplatin and doxorubicin in patients with recurrent ovarian cancer and peritoneal carcinomatosis.

Clemens B Tempfer,Urs Giger-Pabst,Veronika Seebacher,Miriam Petersen,Askin Dogan,Günther A Rezniczek

Gynecologic Oncology（2018）

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摘要

•Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new form of intraabdominal drug delivery.•Patients were treated with PIPAC in a phase I dose escalation study.•No dose limiting toxicities were found after 3 escalation steps.•PIPAC with doxorubicin (2.1 mg/m2) and cisplatin (10.5 mg/m2) may be safely applied into the abdomen.

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关键词

Ovarian cancer,Intraperitoneal chemotherapy,PIPAC,Pressurized chemotherapy,Cisplatin,Doxorubicin

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