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TOLERANCE INDUCTION BY DELAYED NON-MYELOABLATIVE IRRADIATION IN A LARGE ANIMAL LUNG TRANSPLANTATION MODEL

K. S. Hacker,K. Jansson,J. Hahn,W. Sommer,M. Avsar,J. Salman,T. Siemeni,A. -K. Knoefel,L. Ahrens,T. Nakagiri,A. Haverich, G. Warnecke

JOURNAL OF HEART AND LUNG TRANSPLANTATION（2019）

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Abstract
Previously, we induced longterm allograft acceptance in our allogeneic lung transplantation (LTx) model in miniature swine. Animals underwent perioperative non-myeloablative Irradiation (IRR) combined with the infusion of donor specific alloantigen (SpTx). To improve clinical applicability, we delayed induction with irradiation in this study.
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Key words
irradiation,transplantation,tolerance,non-myeloablative
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