Circulating PANDER concentration is associated with increased HbA1c and fasting blood glucose in Type 2 diabetic subjects.

•PANcreatic-DERived factor (PANDER) is a novel hormone regulating glucose levels.•Fasting PANDER levels were measured in T2D and non-T2D matched subjects from U.S.•Associations between PANDER and other hormones or metabolic parameters were examined.•PANDER was associated with increased HbA1c and fasting blood glucose in T2D subjects.•PANDER was not associated with adiponectin, HOMA-β and HOMA-IR.