Synthesis of a glibenclamide cocrystal: full spectroscopic and thermal characterization.
Journal of Pharmaceutical Sciences(2018)
Abstract
A cocrystal of glibenclamide, an antidiabetic drug classified as type II compound according to the Biopharmaceutics Classification System, has been synthesized using tromethamine as coformer in 1:1 molar ratio, by slow solvent evaporation cocrystalization. The cocrystal obtained was characterized by X-ray powder diffraction, differential scanning calorimetry, Raman, mid infrared, and near-infrared spectroscopy. The results consistently show the formation of a cocrystal between active pharmaceutical ingredients and conformer with the synthons corresponding to hydrogen bonding between hydrogen in amines of tromethamine and carbonyl and sulfonyl groups in glibenclamide.
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Key words
co-crystals,FTIR,calorimetry (DSC),X-ray powder diffractometry,near-infrared spectroscopy,Raman spectroscopy
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