Eeffects Of Compound Amino Acids And Ginsenosides On Physiological Measures

Background and Objective: The low capacity of body in the absorption of ginsenosides presents an important question as how to effectively improve absorption, which remains a subject of broad and current interest among researchers. This study aimed to investigate the effects of compound amino acids and ginsenosides on the visceral organ index and blood lipid profile and to assess the absorption rate of ginsenosides and amino acids. Materials and Methods: Male ICR mice were randomly assigned to 7 groups (12 mice/group): Group I (saline control), Group II (ginseng), Group III (composite ginsenosides), Group IV (compound amino acids), Group V (amino acids and ginsenosides, high dose), Group VI (amino acids and ginsenosides, middle dose) and Group VII (amino acids and ginsenosides, low dose) who were treated with the corresponding drugs by gavage for 4 weeks. Weight, visceral index, blood lipid profiles and absorption rates of the mice were then analysed and compared using one-way ANOVA. Results: The middle dose of compound amino acids and ginsenosides increased the body weight of the mice without influencing the liver, lung, kidney, testis, spleen or thymus indexes (p>0.05). Compound amino acids and ginsenosides reduced blood lipid levels, including CHO, TG, HDL-C and LDL-C. HPLC and amino acid analyses revealed that compound amino acids could significantly improve p<0.05 the absorption rate of ginsenosides in mice (p<0.05), especially in the middle-dose group. Conclusion: Supplemental compound amino acids may be helpful for ginsenoside uptake by visceral organs. In addition, the beneficial effects of ginsenosides include body weight increase and blood lipid reduction.