The effects of epothilone D on microtubule degradation and delayed neuronal death in the hippocampus following transient global ischemia.
Journal of Chemical Neuroanatomy(2019)
摘要
•Low doses of Epothilone D slightly rescue the ischemia-induced CA1 neuronal death.•Low doses of Epothilone D slightly alleviate the ischemic damage to microtubules.•High doses of Epothilone D are ineffective against the ischemic damage to area CA1.•High doses of Epothilone D produce additional damage in the dentate gyrus.
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关键词
Microtubule,Cerebral ischemia,Hippocampus,Epothilone D
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