The effects of epothilone D on microtubule degradation and delayed neuronal death in the hippocampus following transient global ischemia.

•Low doses of Epothilone D slightly rescue the ischemia-induced CA1 neuronal death.•Low doses of Epothilone D slightly alleviate the ischemic damage to microtubules.•High doses of Epothilone D are ineffective against the ischemic damage to area CA1.•High doses of Epothilone D produce additional damage in the dentate gyrus.