Interleukin-18 promotes fibroblast senescence in pulmonary fibrosis through down-regulating Klotho expression.
Biomedicine & Pharmacotherapy（2019）
Abstract
•IL-18 induces primary lung fibroblast senescence by down-regulating Klotho expression.•Overexpression of Klotho protects lung fibroblast against senescence induced by IL-18.•Neutralization of IL-18 by IL-18BP ameliorates lung fibroblast senescence in bleomycin-induced pulmonary fibrosis mice.
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Key words
Pulmonary fibrosis,IL-18,IL-18 binding protein,Fibroblasts,Klotho
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