The Effect of Ferulic Acid on Cognitive Disorder And Brain Structural Deficit in Mice in Cuprizone Induced Animal Model of Multiple Sclerosis

Background and Objective: Ferulic acid is a polyphenolic compound derived from some fruit and different cereals. Previous studies have shown that this compound has antioxidant, anti-apoptosis, and differentiation properties in the nervous system. The aim of this study was to evaluate the effect of ferulic acid on the death of oligodendrocytes and demyelination in male C57B6 / J mice in cuprizone induced animal model of multiple sclerosis. Material and methods: In this study, demyelination was induced by oral administration of rats with the 0.2% cuprizone that was added to the usual diet during 6 weeks. Animals were fed daily with ferulic acid at doses of 10or 100 mg / kg of body weight. At the end of the sixth week, the passive avoidance and Y maze test were performed. Then, animal brains were removed and fixed to histological studies using Luxol–Fast-Blue staining Results: The results of this study showed that ferulic acid reduced the random entry of animals into the arms of the Y maze in compared to the cuprizone treated group [p less-than 0.01], but the sequential entry of animals into the Y maze were significantly increased [P less-than 0.05]. A significant improvement in passive avoidance test was observed in the groups treated with ferulic acid at dose of 10 [p less-than 0.05]. Histological evaluations showed the lower demyelination in Luxol-Fast-Blue in the group treated with ferulic acid. Conclusion: The results of this study showed that ferulic acid plays a neuroprotective role in cuprizone models of multiple sclerosis through reducing neuronal demyelination and oligodendrocytes death. Key words: Ferulic acid, Demyelination, Memory, Cuprizone, Mice Funding: This research was funded by Shahid Sadoughi University of Medical Sciences Conflict of interest: None declared. Ethical approval: The Ethical Committee of Shahid Sadoughi University of Medical Sciences approved the study. How to cite this article: Ghobadi M, Arji roodsari B, Yadegari M, Homayouni-Moghadam F, Rezvani M.E. The Effect of Ferulic Acid on Cognitive Disorder And Brain Structural Deficit in Mice in Cuprizone Induced Animal Model of Multiple Sclerosis. J Rafsanjan Univ Med Sci 2017; 16(6): 541-52. [Farsi]