Phagocyte NADPH oxidase, oxidative stress and lipids: anti- or pro ageing?

Laura Baciou,Rawand Masoud,Hager Souabni,Xavier Serfaty,Gilda Karimi,Tania Bizouarn,Chantal Houée Levin

Mechanisms of Ageing and Development（2018）

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摘要

•Nox2 is inhibited by Reactive Oxygen Species mostly because of oxidation of membrane lipids.•The activity of Nox2 in untreated hypercholesterolemic patients is lower than that of normal patients.•Addition or diminution of cholesterol in cell free system leads to a decrease of activity of Nox2.•Oxysterols and non-oxidized cholesterol have similar effects.

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关键词

NADPH oxidase,Oxygen free radicals,Lipids,Cholesterol

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