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Only SETBP1 hotspot mutations are associated with refractory disease in myeloid malignancies.

Nils Winkelmann,Vivien Schäfer,Jenny Rinke,Alexander Kaiser,Philipp Ernst,Sebastian Scholl,Andreas Hochhaus,Thomas Ernst

Journal of cancer research and clinical oncology（2017）

Cited 8|Views10
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Abstract
Patients with SETBP1 hotspot mutations suffered from aggressive disease with rapid evolution and inferior overall survival. Patients with SETBP1 non-hotspot mutations had less aggressive disease and a more favorable prognosis. Diagnostic screens for SETBP1 hotspot mutations may help identifying this dismal patient group and treat them in multicenter clinical studies.
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Key words
SETBP1 hotspot mutations,sAML,MDS/MPN,Leukemia-associated genes,Myeloid malignancies
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