Efficacy of Hybrid Vitamin D Receptor Agonist/Histone Deacetylase Inhibitors in Vitamin D-Resistant Triple-Negative 4T1 Breast Cancer.

Bijian Krikor,Kaldre Dainis,Wang Tian-Tian,Bouttier Manuella,Boucher Annie,Alaoui-Jamali Moulay,White John H,Gleason James L

The Journal of Steroid Biochemistry and Molecular Biology（2018）

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摘要

•Bifunctional hybrids containing vitamin D receptor agonist and histone deactylase inhibitor activity are described.•Hybrids are highly antiproliferative against vitamin D-resistant, triple-negative 4T1 breast cancer cells in vitro and in vivo.•Hybrids are efficacious at reducing 4T1 lung metastases.

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关键词

Vitamin D,Histone deacetylase inhibitors,Hybrid molecules,Breast cancer

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