A Cluster Of Enhancer Modules Directs Differential Myc Expression Along The Normal And Leukemic Hematopoietic Stem Cell Hierarchies

Carsten Bahr, Lisa von Palekse,Veli Vural Uslu,Silvia Remeseiro,Naoya Takayama,Stanley W.K. Ng,Alex Murison,Katja Langenfeld,Massimo Petretich,Roberta Scognamiglio,Petra Zeisberger,Amelie S. Benk,Ido Amit,Peter W. Zandstra,Mathieu Lupien,John E. Dick,François Spitz,Andreas Trumpp

BLOOD（2017）

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摘要

Large enhancer regions, known as “super-enhancers”, have been described as critical regulatory units governing cell identity, but their actual contribution to stem cell-driven hierarchies remains poorly understood. The transcription factor MYC has critical roles in the regulation of hematopoietic stem cells (HSCs) and progenitors as well as in hematopoietic malignancies.

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differential myc expression,enhancer modules

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