The Answer'S In The Tail: Myc Mrna Has A Metabolic Sensor That Supports Cancer Chemoresistance
MOLECULAR & CELLULAR ONCOLOGY（2017）
摘要
Our recent study shows that the translation of MYC mRNA (mRNA) is controlled by its 30 untranslated region (UTR) in a process that depends on the availability of glutamine and levels of cellular nucleotides. Metabolic feedback protects cells from a lethal glutamine addiction and may compromise metabolic targeting of glutamine metabolism.
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关键词
Drug resistance, cancer metabolism, glutamine, post-transcriptional regulation
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