Delineating neuroinflammation, parasite CNS invasion, and blood-brain barrier dysfunction in an experimental murine model of human African trypanosomiasis.
Methods(2017)
摘要
•CE-MRI detected significant BBB impairment in mice at 14days following trypanosome infection.•BBB dysfunction increased in a step-wise fashion as the disease progressed.•Parasite DNA was present in the brain tissue on day 7 after infection.•Parasite CNS load continued to rise as the infection advanced.•A neuroinflammatory reaction developed quickly following infection.•The severity of the neuropathological reaction increased at later time-points.•Changes in the CNS are apparent prior to the onset of established stage-2 disease.
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关键词
Trypanosome,Magnetic resonance imaging,Gadolinium,Blood-brain barrier,Mouse model,Sleeping sickness
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