Pregnancy outcome in women with cystic fibrosis related diabetes.

With increasing life expectancy more women with cystic fibrosis and diabetes mellitus become pregnant. We investigated how pre-gestational diabetes (cystic fibrosis related diabetes) influenced pregnancy outcome and the clinical status of these women MATERIAL AND METHODS: We analyzed all pregnancies reported to the French cystic fibrosis registry between 2001 and 2012, and compared forced expiratory volume (FEV1 ) and body mass index before and after pregnancy in women with and without pre-gestational diabetes having a first delivery RESULTS: A total 249 women delivered 314 infants. Among these, 189 women had a first delivery and 29 of these had pre-gestational diabetes. There was a trend towards a higher rate of assisted conception among diabetic women (53.8%) as compared to non-diabetic women (34.5%, p=0.06), and the rate of cesarean section was significantly higher in diabetic women (48% versus 21.4%, p=0.005). The rate of preterm birth and mean infant birth weight did not differ significantly between diabetic and non-diabetic women. Before pregnancy forced expiratory volume was significantly lower in the diabetic group. The decline in forced expiratory volume and body mass index following pregnancy did not differ between the women with and without pre-gestational diabetes CONCLUSION: Pre-gestational diabetes in cystic fibrosis women is associated with a higher rate of cesarean section, but does not seem to have a clinically significant impact on fetal growth or preterm delivery. The changes in maternal pulmonary and nutritional status following pregnancy in cystic fibrosis women were not influenced by pre-gestational diabetes. This article is protected by copyright. All rights reserved.