The flavonoid Xanthohumol interferes with the thyroid hormone axis

Xanthohumol (XN) is the major prenylated flavonoid of the female inflorescences (cones) of the hop plant (Humulus lupulus). It is also a constituent of beer, a major dietary source of prenylated flavonoids, known to interfere with the sex steroid axis. In the present study, we analyzed in vitro and in vivo effects of XN on thyroid hormone transport and metabolism.