MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239

Molecular Immunology(2017)

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摘要
•The expression of MFHAS1 is significantly increased after activating TLR4 signaling pathway.•MFHAS1 inhibits expression of inflammatory factors and plays a role in negatively regulating TLR4 signaling pathway.•MFHAS1 induces cytoplasm translocation of C subunit of PP2A and decreases dephosphorylation of c-Jun at Thr239.
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关键词
MFHAS1,LPS,TLR4 signaling pathway,PP2A,AP-1,c-Jun
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