Structure-function relationships in reconstituted HDL: Focus on antioxidative activity and cholesterol efflux capacity

Alexandre M.O. Cukier,Patrice Therond,Svetlana A. Didichenko,Isabelle Guillas,M. John Chapman,Samuel D. Wright,Anatol Kontush

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids（2017）

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摘要

•rHDL inactivates lipid hydroperoxides (LOOH) in a dose- and time-dependent manner.•ApoA-I/lipid ratio is directly related to LOOH-inactivating capacity of rHDL.•ApoA-I/lipid ratio is directly related to rHDL-induced cholesterol efflux via ABCA1.•Oxidation of apoA-I Met112 residue decreases LOOH-inactivating capacity of rHDL.•Oxidation of apoA-I Met112 residue increases cholesterol efflux to rHDL via ABCA1.

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关键词

Apolipoprotein A-I,Phosphatidylcholine,Lipid hydroperoxides,Oxidized LDL,Met112,ABCA1

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