A novel pleiotropic effect of aspirin: Beneficial regulation of pro- and anti-inflammatory mechanisms in microglial cells.

Diana Kata,Imre Földesi,Liliana Z Feher,Laszlo Hackler,Laszlo G Puskas,Karoly Gulya

Brain Research Bulletin（2017）

引用 26|浏览6

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摘要

•Aspirin was tested in unchallenged and in LPS-challenged pure microglial cultures.•It affected several morphological and functional (phagocytosis) aspects of microglia.•Aspirin strongly reduced their pro-inflammatory IL-1β and TNF-α productions.•It increased the anti-inflammatory IL-10 level in LPS-challenged microglia.•It differentially regulated the expression of a number of inflammation-related genes.

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关键词

AD,Cd,CNS,COX,DIV,DMEM,E18,ELISA,ERK1/2,FBS,GAPDH,Iba1,IL,IκB,LPS,MS,NF-κB,NO,Nos,NSAID,p38-MAPK,PCR,PD,PBS,RT,SEM,SDS,subDIV,TBS,TI,TLR4,TNF-α

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