Microrna-19b Acts As A Sex-Dependent Regulatory Hub For Ptsd And Chronic Widespread Pain Development Following Trauma Exposure

Sarah D. Linnstaedt,Cathleen A. Rueckeis,Kyle D. Riker,Shan Yu,Chieh Chen,Tony King,Christopher Lewandowski,Phyllis L. Hendry,Claire Pearson,Michael C. Kurz,Kathia Damiron,Robert M. Domeier,Israel Liberzon,Samuel A. McLean

BIOLOGICAL PSYCHIATRY（2017）

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摘要

PTSD and chronic widespread pain (CWP) are frequent co-morbid sequelae of trauma that occur at different rates in women and men. We sought to identify microRNA (miRNA) that may contribute to sex-dependent differences in vulnerability to these outcomes using in silico, human, molecular, and animal data.

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关键词

microRNA, PTSD - Posttraumatic Stress Disorder, Chronic widespread pain, Sex differences, Circadian Rhythms

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