Oral delivery of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, synthetic peptide leptin mimetics: Immunofluorescent localization in the mouse hypothalamus.

Brian M Anderson,Lauren Jacobson,Zachary M Novakovic,Patricia Grasso

Brain Research（2017）

引用 12|浏览7

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摘要

•Small orally-active synthetic peptide leptin mimetics.•Improve energy balance and glucose regulation in mouse models of obesity/diabetes.•Cross the blood-brain barrier in leptin-deficient and leptin-resistant obese mice.•Concentrate in the area of the arcuate nucleus of the mouse hypothalamus.•Overcome the leptin transport defect in diet-induced obese (DIO) mice.

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关键词

Blood-brain barrier,Leptin resistance,Leptin mimetics,Diet-induced obesity,Diabetes

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