Characteristics Of Hiv Plus Lung Cancer Cases In A Large Clinical Population: Implications For Long Cancer Screening.

1569 Background: Lung cancer (LCa) accounts for ~30% of cancer deaths and 10% of non-HIV-related deaths among HIV(+)s. Compared to those in the general population, even after accounting for smoking, HIV(+)s have a 2.5–5-fold higher risk of LCa, and are diagnosed younger. The National Lung Screening Trial (NLST) demonstrated survival improvements with low dose CT (LD-CT) screening in persons at high lung cancer risk (age 55-74 with ≥30 pack-years [pys] of smoking). We examined the age and smoking histories of HIV+ LCa patients to determine who would have met NLST screening eligibility. Methods: The Cancer Registry (42,967 cancer cases) and the HIV Integrated Clinical Database (14,927 HIV+s) at Montefiore Medical Center – Einstein (Bronx, NY) were linked to identify HIV+ cancer cases between 2000-2012. Chart review was performed for those with LCa. Results: Of the 935 invasive cancers in HIV+s, 90 (9.6%) were LCa (62% men, 38% women). Histology was 11% small cell, 20% squamous and 37% adenocarcinoma, 2% lar...