Commentary on Inherited Neurovascular Diseases Affecting Cerebral BloodVessels and Smooth Muscle

Neurovascular diseases are a group of highly detrimental human disorders. The diseases are among the leading causes of mortality and long-term disability due to aneurysm, stroke and other cardiovascular complications in both children and adults, becoming a serious hazard to human health, and bringing heavy burden to community and the patients’ family [1]. In most cases, neurovascular diseases have complex genetic traits [2]. The pathogenesis of the disease is sophisticated,. For example, cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is due to the co-effects of genetic and environmental factors [3]. So far, advances in human genomics have provided tools for identification of genetic variants underlying complex traits, and have been applied to neurovascular diseases studies. The main task of present studies is to identify the genetic defects involved in the pathogenesis of neurovascular diseases