Prognostic Significance Of Focal Adhesion Kinase (Fak) In Node-Negative Breast Cancer.

552 Background: Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase playing an important role as a key mediator for signal transduction. We examined the subtype specific prognostic significance of FAK in node-negative breast cancer. Methods: Using microarray based gene-expression data, we analysed the prognostic significance of FAK (208820_at). The subtype specific prognostic role of FAK was analysed in four previously published cohorts (Mainz, Rotterdam, Transbig, Yu) of node-negative breast cancer patients not treated with adjuvant therapy (n = 824). A meta-analysis of previously published cohorts was performed using a random effects model. Prognostic significance of FAK for metastasis-free survival (MFS) was examined in the whole cohort of patients as well as in different molecular subtypes: luminal A (ER+/HER2-/aurora kinase A [AURKA]low, luminal B (ER+/HER2-/AURKAhigh), basal-like (ER-/HER2-), and HER2+. Results: Prognostic significance of FAK was seen in the whole cohort of patients (HR 1.4...