Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice.

Marilyn J Duncan, Hannah Farlow, Chairtra Tirumalaraju, Do-Hyun Yun,Chanung Wang, James A Howard,Madison N Sanden,Bruce F O'Hara,Kristen J McQuerry,Adam D Bachstetter

Alzheimer's & Dementia: Translational Research & Clinical Interventions（2019）

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摘要

•Daily DORA-22 treatment at light onset for 5 weeks increased sleep in 5XFAD mice.•DORA-22 mainly increased sleep during the light (inactive) phase.•Chronic DORA-22 treatment did not affect cortical amyloid β levels or plaques.•Chronic DORA-22 treatment did not alter cortical neuroinflammation.

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关键词

Sleep-wake cycles,Sleep fragmentation,Orexin,Dual orexin receptor antagonist,Amyloid β,Neuroinflammation,Alzheimer's disease

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