Multi-Omics Strategies Uncover Host-Pathogen Interactions.

With the success of the Human Genome Project, large-scale systemic projects became a reality that enabled rapid develop-ment of the systems biology field. Systems biology approaches to host-pathogen interactions have been instrumental in the discovery of some specifics of Gram-negative bacterial recognition, host signal transduction, and immune tolerance. Howev-er, further research, particularly using multi-omics approaches, is essential to untangle the genetic, immunologic, (post) tran-scriptional, (post) translational, and metabolic mechanisms underlying progression from infection to clearance of microbes. The key to understanding host-pathogen interactions lies in acquiring, analyzing, and modeling multi-modal data obtained through integrative multi-omics experiments. In this article, we'll discuss how multi-omics analyses are adding to our un-derstanding of molecular basis of host-pathogen interactions and systemic maladaptive immune response of the host to mi-crobes and microbial products.