Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement
Nature Communications(2017)
Abstract
Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential ‘on-off’ switch of pDC activity with therapeutic potential.
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Key words
Plasmacytoid dendritic cells,Virus–host interactions,Science,Humanities and Social Sciences,multidisciplinary
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