Matrix metalloproteinase-7 inhibitory activity of lipid extract from dwarf gulper shark (Centrophorus atromarginatus) through down-regulation of gene transcription
Journal of Functional Foods(2017)
Abstract
•Lipid of dwarf gulper shark muscle attenuated MMP-7 activity in casein zymography.•Shark muscle lipid decreased extracellular secretion of MMP-7 protein.•Ganglioside GD1 and GM1 were suggested as active component in shark muscle.•Down-regulation of mmp-7 was induced by GD1a through change of c-jun transcription.
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Key words
BSA,FBS,MMP
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